Having conquered television, the ladies of Wisteria Lane will next take on the music world.

A soundtrack for "Desperate Housewives," featuring an impressive array of female artists ranging from Shania Twain to Liz Phair, is set to hit stores Tuesday, Sept. 20 -- five days before the show begins its second season on ABC. "Music From and Inspired by Desperate Housewives" comes from Hollywood Records, which like ABC is part of Disney.

Twain will contribute a new song called "Shoes" to the album, which features a mix of original tunes and covers, as well as Danny Elfman's Emmy-nominated theme music and snippets of dialogue from the show.

Phair will contribute a thematically appropriate cover of the Rolling Stones' "Mother's Little Helper," while country star Martina McBride will do a version of "Harper Valley PTA." The Indigo Girls are on board for a cover of Simon & Garfunkel's "Mrs. Robinson." Gloria Estefan, k.d. lang, Macy Gray and Joss Stone are also set to record songs for the soundtrack.

"Desperate Housewives" is up for 15 Emmy Awards next month, including outstanding comedy series. Cross, Hatcher and Huffman are all nominated for best lead actress in a comedy.